Keen interest exists in whether caffeine consumption has an intraocular pressure (IOP)-modifying effect, as elevations in ocular tension can increase glaucoma risk.
Many studies have examined various caffeine-containing substances and their potential link with IOP. Most studies observed modest acute IOP increases in the four hours after ingestion. But fewer studies have examined the relationship between habitual coffee consumption and IOP or glaucoma risk. This is important because habitual coffee consumption can modulate the effects of acute caffeine consumption on IOP.
What's more, studies of the relationship between coffee drinking and glaucoma risk have reported conflicting results, with it suggested the association may depend on family history of glaucoma.
Indeed, genome-wide association studies (GWASs) indicate that IOP is a polygenic trait, and a higher IOP polygenic risk score (PRS) is associated with a higher risk of primary open-angle glaucoma (POAG).
The current study, by researchers base din the UK and US, aimed to resolve conflicting data on the relationship between habitual coffee or caffeine consumption and IOP. Using UK Biobank data, the team evaluated multivariable-adjusted associations with IOP and glaucoma. For both outcomes, the team examined gene–diet interactions using a polygenic risk score (PRS) that combined the effects of 111 genetic variants associated with IOP.
The resulting data suggests that habitual caffeine consumption is associated weakly with lower IOP, and the association between caffeine consumption and glaucoma is null. However, among participants with the strongest genetic predisposition to elevated IOP, greater caffeine consumption was associated with higher IOP and higher glaucoma prevalence.
"consumption" - Google News
June 10, 2021 at 05:56PM
https://ift.tt/3vauIsM
High caffeine consumption could increase glaucoma risk if genetically prone - NutraIngredients.com
"consumption" - Google News
https://ift.tt/2WkKCBC
https://ift.tt/2YCP29R
Bagikan Berita Ini
0 Response to "High caffeine consumption could increase glaucoma risk if genetically prone - NutraIngredients.com"
Post a Comment